I've used staples on the connector that goes from my run to my coop - I built the connector out of old pallets and then put chicken wire across the top, stapled, and used extra boards from pallets to screw down over the top of the staples.
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Oh yeah
On my actual runs - one is an old dog kennel 10X10X6 with chain-link fencing and chicken wire - that's where I keep extra cockerel's that will be processed, or any quarantine birds if it's not in use otherwise. The other run is my main one - it's 10X20X6 and the framework of it is made out of PVC. I had originally planned it to be mobile, so I could move it through the yard...but um..yeah, right. So anyway - it's stationary
I used zip ties to fasten the chicken wire and hardware cloth to it - zip ties are about every 2 inches...it took a lot of zip ties. Here's a photo for an idea, and you can also see my improvised door lock I made out of some chain link fencing supplies, a threaded metal rod and a couple of nuts. It secures the door rather well - but to be honest, had I researched a bit more prior, I would have just built the run out of wood.
On the top of my runs, I only have chicken wire - I used hog rings to secure the seams of the wire. Then I have shade tarps over the main run, and the dog kennel has a tarp frame/cover over it. My main concern here is hawks, with of course the occasional raccoon. I've seen dozens of snakes in my yard this year, but none near the chickens. We have enough field mice, frogs, birds, and moles ... the snakes don't care at all about my chickens or eggs fortunately.
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I think really - we all obsess at some point on security of our babies, but ultimately we do what we can with the resources we have until we can do better. I'm always looking for ways to tweak what I've got and improve on it. I can't tell you how many good ideas I've found on this site just by reading through the forums.