Here's the back story..... Last week I lost a hen who had discharge coming out of her nostrils and very watery eyes. She was also extending her neck and had some breathing difficulties (minor crackling/gurgling). Before I could treat her appropriately, I lost her. I put ACV and vitamins/electrolytes in the water and have continued since then hoping to avoid more sick birds. Yesterday, I noticed a young pullet (3 mo old) with swollen, watery eyes and she was lethargic. She also had a bit of a smell to her. My initial thought was Coryza (she is the only symptomatic bird that has had this "smell" by the way). It's been below freezing here in MN, so I brought her inside and gave her .25ml of Tylan 50 and put VetRx on her. Her eyes have been sealed shut off/on and I've been using Neosporin to help relieve eye symptoms. Once delivered, I'll start using Terramycin on her eyes. I gave her a second dose of Tylan last night and another this morning. The initial smell I sensed from her has dissipated greatly. She also took about 5cc's of water this morning and she at some scrambled eggs with my help since her vision is impaired. Later yesterday, I noticed more sneezing in the coop and watery eyes in a few more of my younger pullets. I brought them all into the garage and started them on Tylan. Second dose was given this morning. Aside from the initial deceased hen, I have only seen similar symptoms in one other of my older 10mo old girls. She is currently being treated, but has not had eye or lethargic symptoms like my younger pullets. Just respiratory with extending her neck and gurgling. She eats and drinks fine from what I have seen. My question is, I do have Duramycin on hand and Sulmet will be delivered tomorrow. I do expect this to travel through the entire flock even with separating birds. If it doesn't spread, I consider myself very lucky. I did gut out the coop and disinfected what I could, but they've all been exposed. I will cull if I have to, but I'd like to see if I can resolve this first. I don't want to over medicate my girls or medicate them for no reason, but should I add the Duramycin or Sulmet to the water for everyone? Then, only use Tylan injections for the obvious symptomatic birds in addition to the water treatments? Thanks in advance!