Good question! I would think it would evaporate quicker, so you'd have to run it at higher humidity (so heck, why not go ahead and pop it in, then keep the humidity up after the first hatch?). Also would probably be more susceptible to bacteria and what-not. But other than that, I don't see why it couldn't hatch. It would probably be similar to hatching a double-yolker in that it usually won't work, but maybe sometimes it would. I think you should pop it in and see!