All my birds, (turkeys, Ducks, chickens, geese and Guineas) all get along with each other. Sometimes every once in a while a male will get a little fresh with another male of another species, but for the most part they just co exist just fine. They probably won't be running around frolicking in the daisies together but they won't be fighting or hurting each other. Besides, chicken hens won't want to establish any dominance, so a male Muscovy won't want to display any, and regardless, your hens will just run away if a male gets a little frisky. But he shouldn't. If you provide a decent little setup WHEN you do free range, they won't want to go anywhere anyways. But pinioned muscovies will know from the beginning to not even attempt to fly. They will just flop over. So they dont even try ive never had any of my birds even just up on my 4 foot fence. Just keep them happy, and happy when free ranging is diverse and plenty of foraging food or whatever. Twice a day I throw few bowls worth of scratch grains down but in a wide throw. It keeps them busy a while.
As far as how much room they need, I can't really answer that because I have a lot of birds crammed into a barn, they fit just fine, but they literally go in to sleep and lay eggs. And I keep their bedding super dry and clean. They have access to their yard all day. They literally sleep in there. And it works. But keeping them penned up for extended periods of time I would imagine you would want to give them a bit of space.
How often do you plan on letting them out to forage?