Well... I had a call who was colored like a male but quacked like a female... Never layed eggs... nothing.. She now lives with my Grandma and is paired with a female...
It hasn't changed gender. In all likelyhood, it has an ovarian tumor that has reduced the amount of estrogen it produces. When the amount of estrogen is produced, plaumge characteristics of drakes become apparent.
Oh how sad! I am so glad my third hen started laying this morning. I have one hen that quacks like a drake, but looks like a hen, and I thought she was "transgender" or something until this morning. Hadn't considered tumors and medical reasons for the quack/look/lack of eggs
Not neceessarily cancer, but very possible. It could be damage to the ovary, hypothalmus issues with gonadotropion releasing hormones, some denetic defect affecting the number and types of cellular receptors. etc.