Hi NC stalker -
Thank you for the response. None of my birds are listless nor do they have fluffed up feathers. A few weeks ago, I did notice that one of my EE's was giving me eggs with thin shells that would break easily; I suspect she has since stopped laying completely. I'm eating some sunny-sides right now from eggs I collected yesterday, and they are just fine. Other than one egg-bound bird 4 years ago, and one day-old chick a few years back, I have only lost birds to predators. I'm hoping that is not about to change. Right now the 3 bubbly eyed birds are standing on my deck, preening and behaving perfectly normal. On two of those birds you have to pick them up and look closely to see the bubbles. The third I can tell from further away. None has swollen wattles nor any other symptom that I can see.
I have my birds for egg production for my family and a few friends. I don't sell birds, nor do I show them so I won't cull my flock, but I don't think I will be adding to it either; at least not until I get this under control. I know they will now always be carriers even if they show no symptoms. I think my LF flock will always be susceptible to diseases from wild birds as they have access to free-range from dawn until dusk. I have just been lucky until this point. If I lose a bird, I may send it to Pullman for a necropsy.
Searching bubbly eyes on BYC, it looks like lots of people have had success treating it and whatever infections have caused it with Tylan, Duramycin or Sulmet, but of those 3, Tylan is the only one approved to be used on a layer flock, and the one that seems to get the best reviews. I can do that now, and treatment is only 3 days. I can do that far quicker than waiting for a bird to die and sending it in for necropsy. I just need to know if I use the injectable form, do I use a fresh needle for each bird each day? and can I inject some birds and treat the drinking water for others? (I'm thinking of injecting the free-range flock and treating the water for the pullets since they are showing no symptoms but roost in close proximity to the layer flock)