Picasso for the no brainer stuff, Photoshop Elements for the easy stuff, Lightroom for my wedding and some portriat photography and the creme de la creme, Portriat Professional. I guess you can tell I'm an Adobe girl
I love my orginal lense baby, I can get alot of cool effects out of it.
I currently use GIMP (Ubuntu user for the moment) but I really did enjoy Fireworks, Photodraw (back when it was actually in production) and Photoshop (although it is kinda overrated)