....
And again I have lost interest in followingvthe research further.
...
Maybe I'll go a little further
Next.
She says "The chemicals responsible for causing liver stress and damage in animals are most likely the terpene hydrocarbons and aromatic compounds in pine (Miyamoto et al., 2008; Li et al., 2009).
https://www.researchgate.net/public...ve_and_recycle_bedding_for_laboratory_animals
"...We developed a ground-breaking system to improve fresh bedding and recycle used bedding by applying a soft hydrothermal process with high-temperature and high-pressure dry steam....
The purpose of the present study was to evaluate the chemical and physical properties of the [bedding]...
we have been maintaining mice for several months and analysing their growth and blood components. So far, the data have indicated few differ-
ences except for a suppression in the induction of P-450, a microsomal enzyme in liver, when compared with animals
maintained using fresh bedding (data will
be presented elsewhere)."
Soooooo.... that source doesn't focus on the effects of terpene hydrocarbons and aromatic compounds on liver stress and damage? But might give a few threads to pull - "suppression in the induction of P-450, a microsomal enzyme in liver,"
"P-450, a microsomal enzyme in the liver"
I don't know what that is. So...
https://en.m.wikipedia.org/wiki/Cytochrome_P450
Short version -
"CYP enzymes have been identified in all
kingdoms of life:
animals,
plants,
fungi,
protists,
bacteria, and
archaea, as well as in
viruses. ...[In humans] Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in
hormone synthesis and breakdown (including
estrogen and
testosterone synthesis and metabolism),
cholesterol synthesis, and
vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including
drugs and products of endogenous metabolism such as
bilirubin, principally in the
liver....
CYPs are the major enzymes involved in
drug metabolism, accounting for about 75% of the total metabolism.[23] Most drugs undergo deactivation by CYPs, either directly or by facilitated
excretion from the body. Also, many substances are
bioactivated by CYPs to form their active compounds like the
antiplatelet drugclopidogrel and the opiate
codeine...."

The liver seems to be processing. That isn't damage. The liver is supposed to process all kinds of things produced by the body and from outside the body.
The other threads to pull are the studies this author references. But first, Li.