Can chickens take "Erythromycin Ethylsuccinate?"

[Kim Austin]

Can chickens take "ERYTHROMYCIN ETHYLSUCCINATE"?

 

[tridentk9]

The first question should be is the bacteria causing the problem sensitive to erythromycin?

 

[tridentk9]

http://www.drugs.com/pro/gallimycin-pfc.html

The product label does say eggs are no longer safe for consumption. No time limit so they mean forever. Personally, I wouldn't use the eggs on any species not just humans.

WARNING:

Do not use in chickens or turkeys producing eggs for human consumption.

Do not use in replacement pullets over 16 weeks of age.

Withdraw on (1) day before slaughter.

 

[dawg53]

According to this European link, erythromycin has a 6 day egg withdrawal period:
http://www.interchemie.com/veterinary-products/poultry/gallimix-200-ws.html
Another link I saw stated that it had a 1 day slaughter withdrawal period. Studies for egg withdrawal periods in most meds are too time consuming, expensive, as well as liability aspects for pharmaceutical companies to test these products.
Another example is wazine. The label states not to eat the eggs after using the product. There's a 14 day slaughter withdrawal period stated on the bottle for chickens. If the chicken is good to eat after 14 days, so are the eggs.
With erythromycin, either a 1 day or 6 day (European slaughter withdrawal period,) like wazine... if the meat is good to eat, so are the eggs.
I've used wazine and other wormers in my birds and have eaten eggs after the withdrawal periods, still here typing. A lot of folks have eaten eggs directly after using antibiotics and wormers, that's their choice. I abide by slaughter withdrawal periods if there arnt any egg withdrawal periods.
http://web2.uconn.edu/poultry/poultrypages/diseasefactsheet.html
Scroll down to "Medications" in the above link.

 

[tridentk9]

According to this European link, erythromycin has a 6 day egg withdrawal period:
http://www.interchemie.com/veterinary-products/poultry/gallimix-200-ws.html
Another link I saw stated that it had a 1 day slaughter withdrawal period. Studies for egg withdrawal periods in most meds are too time consuming, expensive, as well as liability aspects for pharmaceutical companies to test these products. 



I've used wazine and other wormers in my birds and have eaten eggs after the withdrawal periods, still here typing. A lot of folks have eaten eggs directly after using antibiotics and wormers, that's their choice. I abide by slaughter withdrawal periods if there arnt any egg withdrawal periods.
http://web2.uconn.edu/poultry/poultrypages/diseasefactsheet.html
Scroll down to "Medications" in the above link.

Sounds reasonable with one caveat- I am not sure if or how but it is possible (again I don't know) that the hen can concentrate more of the medications in the egg than throughout the whole body. I probably wouldn't eat the liver or kidneys for a lot longer than the five day day washout period as most meds are filtered out by one or both of those organs.

There is a huge difference between dewormers and antibiotics. ABs can and do affect more than just the original consumer of eggs or meat. Made worse by the human tendency to only treat until the patient is better and not finish recommended treatment times. Medicating this way only increases the percentage of resistent bugs, a very real worldwide threat.

Sigh, I don't disagree with you- I disagree with the reasoning. Given the human body, there may still be a deleterious effect from the medications but cause and effect may be minimal in an adult or separated by time.

 

[tridentk9]

Possibly more information than you wanted. Basically drug residues depend on how a drug is absorbed and then excreted by the chicken. Since egg yolks start being formed weeks before the egg is laid, a drug can potentially show up in eggs for a month after the drug is stopped. Charts throughout the article are broken down by drug class and show how long most drugs used in chickens can be detected.

From another article, the type of chicken, broiler vs layer, can also make a difference in excretion rate.



http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01287.x/full

In poultry, antibiotics and antiparasitics are used extensively for disease prevention and treatment. In the United States, antibiotics are also used for growth promotion, although this type of use has been prohibited in the European Union since 2006. Edible tissues containing veterinary drug residues can pose risks to human health, including direct toxic effects, allergic reactions and increased bacterial resistance to common antibiotics.

Drug residues in chicken eggs are of concern because relatively few drugs are labelled for laying hens, although several medications are approved for other production classes of poultry. Drug residues in eggs may arise when laying hens are mistakenly given medicated feed, when feed is contaminated at the mill during mixing, or when drugs are given off-label. While a chicken lays an egg roughly every 24 h, each egg takes several days to develop in vivo, and some egg components are in existence months before the fully developed and shelled egg containing them is laid. Because of the protracted nature of egg development, many weeks may be required following treatment or exposure before eggs are free of drug residues.

It should be noted that some drugs included in this review are prohibited from use in some or all food animals in the US and/or the EU. In the US, extra-label use of fluoroquinolones is prohibited in food animals, and any use of these drugs in a manner not explicitly approved is illegal. If an animal is mistakenly or intentionally treated with a drug that is prohibited from extra-label drug use, then the exposed animal(s) should not enter the food chain unless permission is granted from the proper authorities. In both the US and EU, other drugs, including chloramphenicol, the nitroimidazoles, and nitrofurans, are completely prohibited from use in food animals. A summary of drugs approved in the US for game bird species has been published, and a recent update on drugs prohibited from extra-label drug use in the US is available. EU approval statuses and maximum residue limits for veterinary drugs used in food-producing animals are described in the European Commission Regulation 37/2010.

Of the three main egg components (yolk, albumen, and shell), the yolk has the longest development time. Precursors to yolk lipoproteins are produced in the liver and transported through circulation to the yolk follicles in the ovary. In an actively laying hen, several follicles at varying developmental stages reside simultaneously in the ovary. Before an egg is laid, the yolk undergoes a stage of rapid growth, in which it increases in size exponentially over 10 days. Drugs that deposit in the yolk will rapidly accumulate during this time and can be present in successive eggs for 10 or more days following treatment. Following yolk maturation, the albumen or ‘egg white’ is laid down over a period of 2–3 h and can also serve as a residue accumulation site. The egg shell is added after albumen proteins are deposited and diluted with water. The egg development process is similar across species of poultry and game birds, although the rates of development vary. A detailed diagram of a chicken egg is shown in Fig. 1.

image
Figure 1.  Detailed illustration of the components of a developing avian egg.

Many drugs deposit preferentially in the yolk or albumen, depending on the drug’s physicochemical properties. Some characteristics that effect the distribution of residues are the drug’s tendency to bind to plasma proteins, hydrophobicity or hydrophilicity, and the ability to move through different tissue types. However, a drug’s kinetic properties cannot always be predicted from its chemical properties. This review presents a compilation of studies found scattered throughout the literature that address the kinetics of veterinary drugs in laying hens.