I started with Ivermectin
from :http://www.inchem.org/documents/pims/pharm/ivermect.htm
.4 Teratogenicity
The rates of major congenital malformations are not altered in
treated mothers. In a Liberian community-based ivermectin
therapy programme, the incidence of major congenital
malformations in children born both to ivermectin-treated and
untreated mothers was about 2.5%, a figure comparable with
rates previously reported in the population at large in Africa
(WHO, 1990b).
No adverse effects were reported when pregnant mares were
given six oral doses of ivermectin 0.6 mg/kg paste at two-week
intervals during organogenesis and early pregnancy, and six
intramuscular injections of ivermectin at 0.6 mg/kg at two-
month intervals during the last two trimesters. The foals
born were also unaffected (Campbell & Benz, 1984).
Ivermectin is teratogenic in rats, rabbit and mice at or near
materno-toxic dose levels. The abnormalities are limited
mainly to cleft palate. Mice are the most sensitive species
to the effect of ivermectin with maternotoxicity at a dose of
0.2 mg/kg/day (MSD, 1988).
7.5 Mutagenicity
Ivermectin was negative in the AMES Assay, and in a mouse
lymphoma mutation assay. In addition, it did not induce
unscheduled DNA synthesis in a human fibroblast cell culture,
suggesting that it does not damage DNA (MSD, 1988)
There is nothing on poultry but sufficient on other animals to suggest it wont harm them. The issues were at near toxic doses, not routine doses.
Last edited:
