17 center fires work great...flat and fast, used them for Fox in MNIf you are just preparing for chance encounters with a yote and are not Mathew Quigley i suggest a 12 or 20 gauge with #4buck. If you are all set up in a blind with a rest and are calling them in then most anything will do it if you can do your part. If im not pelt hunting ill use the biggest thing i can hit em with. If worried about pelts ill take a 17 mag rimfire 22 magnum with fast expanding bullet or222 with light bullet. When they are eating my babies ill take tje 12 gauge