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We had a german shepard, mastiff, great dane mix that at 2 years old was 225 pounds. we also had a rott, coon dog, black lab that at 1 year old was 230 pounds. We currently have an 8 year old St. Bernard, Newfoundland cross that tips the scale at 245 pounds, a 1 year old Great Pyr, border collie that weighs 168 pounds, a 3 year old blue tick heeler, aus. shepard, rat terrior that weighs 48 pounds and a 4 month old Great Pyr. that is tipping the scale at 68 pounds(and of course is still growing). All of our dogs a HUGE....NOT because we are NOT RESPONSIBLE, but because they are large breeds in general (all except the 48 pounder). We feed our dogs VERY well...Not over feeding, not under feeding, we do not fill our dogs with people food or table scraps. They are feed very well and are very well taken care of. I am not trying to sound rude by stating that either I was just taken aback by your statement on large dogs basically come from irresponsible breeders.
I grew up with a 230 Rott that was the biggest baby in the world....There again, he was not raised by irresponsible owners.