for years I have used duramycin -10 I have a show rooster german spitzhauben he got a cold runny eye full blown he would not drink so duramycin not going to work so I got some tyan-50 gave him some an in about 4 hr. he was eatting and drinking that`s it for me if im not treating all my birds then it`s tylan from now on i`ll give him another shot in 48 hrs. like it says it`s only 12 dollars and has a 3 year life so one bottel will go a long way