Is there no coming back from this besides going to the vet? Is my other option to put her down?

I don't think the poultry cell will affect the antibiotics, unless you were watering down the amount in the dose by mixing them. Sometimes it's not recommended to mix meds in drinking water, more because the taste can put them off, and they won't drink enough. I can't find anything that says it makes it less affective, only that taking vitamin C or mixing it (amox.) with acidic things can reduce it's effectiveness. It does look like she might lose the middle toe and the tip of the other. If the rest recovers I think that would still leave her enough of a normal foot that she would do fine. Birds do lose toes to all sorts of accidents.
The other meds I use for infection have been clindamycin and cephalexin, (fish cin and fish flex) both gotten as fish antibiotics, which I've used when amoxicillin was not effective. I don't think Jedd's sells those.
 
I don't think the poultry cell will affect the antibiotics, unless you were watering down the amount in the dose by mixing them. Sometimes it's not recommended to mix meds in drinking water, more because the taste can put them off, and they won't drink enough. I can't find anything that says it makes it less affective, only that taking vitamin C or mixing it (amox.) with acidic things can reduce it's effectiveness. It does look like she might lose the middle toe and the tip of the other. If the rest recovers I think that would still leave her enough of a normal foot that she would do fine. Birds do lose toes to all sorts of accidents.
The other meds I use for infection have been clindamycin and cephalexin, (fish cin and fish flex) both gotten as fish antibiotics, which I've used when amoxicillin was not effective. I don't think Jedd's sells those.
I was asking Chatgpt about it and it said that the high iron content and other minerals can bind to the antibiotics and make it less effective. I'll just give that to her in the evening with the probiotics just to be safe.

It looks like hardypaw.com sells all 3! Fix Sulfa 960, Fix Cin and Fish Flex. Do you have any recommendations on the order to try these if baytril fails?

What has been your experience like with antibiotics in general for bumblefoot?

For the bottom of the foot, would you continue the sugardine at this point? Do you have any experience using manuka honey?
 
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I have used Manuka Honey on occasion. It's generally been better on smaller sized, shallower wounds. I don't see issues with using sugardine, I've used it for very long periods on a couple of really bad foot infections on my birds, never saw anything bad come from it. If you want to switch, you could try it, see what happens. Switch back if it seems to get worse. If the foot is healing, no regeneration of pus for a while, then it may be enough. You just have to watch.
As far a which antibiotic to use, that's kind of a guess without labs/cultures to see. Both clindamycin and cephalexin are sometimes used for staph in humans, it just depends on what kind of staph it is. I personally would probably use clindamycin because I think it is used for more types. There are other meds used in humans as well, but harder to come by without prescription.
I've not had really good results with any antibiotic for treating the bumblefoot infection on it's own. Used in conjunction with other treatments, cleaning, soaking, debridement, etc, it might help, and it can help reduce secondary infections from introducing more bacteria from messing with the foot.
This shows some of the medications used in humans:
https://www.merckmanuals.com/profes...atment-of-staphylococcal-infections-in-adults
 
Obviously dosing for those meds will be much different for a chicken.
Ahh yes, I'll have to figure out the dosing for each antibiotic. Have you had any luck with sending in a sample to a lab to try to figure out what strain of bacteria it is? I didn't realize staph had so many strains.

Although, thinking about what you said about antibiotics, it sounds like doing the external stuff would be more effective anyway. I have to admit I wasn't so great about soaking because I really hate it, but I'll keep doing it. I thought it had to be 20 minutes but it sounds like even 10 minutes is better than nothing.

At this point, I'm pretty sure some part of her will self-amputate, so I'd like to be prepared when that happens. Any advice on healing after self-amputating? I think @Eggcessive might have some experience with this?
 
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