To answer your specific question, I don't give up until day 25. Ever. (There's always been an egg or two or more left over from all of my hatches, so I will wait til day 25 before I shut down the 'bator on any unhatched eggs.)
I've had the very first egg wait until late day 22 to pip. And I didn't hear any peeping until mid-sfternoon that day, as well. By the next morning, most of the hatchlings had zipped through their eggs and were out! They hatched overnight and didn't even let me see 'em do so.
So don't give up yet.