I don't use a needleless syringe. and it's easily diluted.
http://www.dogaware.com/health/ivomec.html
for the mini horses, there are 2 reasons. 1) many people DO remove the paste from the tube, mix well and then divide between animals based on weight. 2) and most importantly! the reasons given to horses vs dogs are entirely different. In horses, you are treating internal parasites. Which, while they can be serious in extreme cases, are rarely deadly.
In dogs, you are treating heartworms. A dog can be easily infected with a single bite and if you end up with a couple months where the dog is getting a too low or even zero dose, the infestation can quickly become life threatening on it's own. Then, if you give a large dose, causing a massive die off, you can send the dog into congestive heart failure within hours of giving the meds.