Just sharing my experience, and yes, Marek's sucks. If you don't have confirmation, get it. As stated, other things can mimic Marek's symptoms, it's better to know for sure, than to guess. Marek's birds are more susceptible to all kinds of other illness due to their weakened immune systems, so it's best to know if Marek's is the underlying reason for other things, or they are the sole cause.
Whether to vaccinate or not is a very personal decision, I wouldn't criticize either decision, ever. We all come from different places in thought and experience. I am not anti vaccine at all, but I've chosen (for now) to try to breed for resistance rather than vaccinate. I know there are vehement opinions on both sides of the discussion, I'm all for educating yourself as best you can, and making a decision that works for you. My strain seems to be on the milder end of the spectrum (which still means losses

), so my decision is based on choosing to lose sick birds rather than keep them alive to basically spew out virus and perhaps a mutation to a worse/more virulent strain. I'm not suggesting that would work for everyone, just my choice. Again, read as much as you can, and make a decision that fits your world.
I do know that silkies are much more susceptible to the virus, I don't have any and won't get any, for that reason. There are some breeds that are known more susceptible, and some breeds are known less susceptible, but individual genetics is
really important. Fayoumi's are supposed to be more naturally resistant, but I have read of people who have lost some. I think EVERY bird has some chance of being susceptible. Genetics in general are really, really complicated and still not fully understood (makes my head hurt!). Resistant birds can have offspring that are not resistant, and it's impossible to predict. None of us likely have access to the resources and $$ to try to do actual genetic testing and track what our breeding is actually doing. It's results based and takes an enormous amount of time. For me, I only hatch from non symptomatic birds. I have one hen that every chick out of her has had symptoms (all hatched before she showed symptoms) so I no longer hatch from her. She is my only feather footed bird, so easy enough to ID her chicks. I have original, unvaccinated birds, and some of their offspring, that have never shown any symptoms, some in the 10 to 12 year old range, including one GLW roo. I lost all my GLW hens, have a couple of GLW/EE crosses left that are non-symptomatic and are in the 6-7 year old range. The only new birds I have brought in since I found out I had Marek's are the fayoumi's I bought last year from Meyer. They are now 1 year old and, so far, none are showing any signs. Fingers crossed. I have endeavored to hatch enough from my non symptomatic birds to keep me going, rather than introduce more birds into the flock with unknown genetics. Though I may in the future, just depends on how my fayoumi's do and how successful I am in crossing some of them with my others with positive outcomes. Eventually I will need to bring in some new genetics, at least a new roo or two. I haven't hatched any from the fayoumi's yet, I usually wait til they are 2 to minimize breeding symptomatic birds, but I may hatch some this year, just to see how it goes. I will be trying to band breeding groups to minimize inbreeding as much as I can, while trying to encourage the more resistant genetics.
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@microchick , my initial losses where heavier, once that period had passed things have calmed down, I lose a few birds here and there, but nothing like how it started. I have a lot of birds that show occular symptoms, and I find visceral tumors in many I lose. I have yet to see the leg paralysis that is commonly mentioned, in my flock. I've lost a few EE's to it, but over all they have been more resistant, some of those I lost were crosses with other pure breeds in my flock. Pure breeds, in my flock have not fared as well as mixed breeds. I'm not a fan of sex links, but my black sex links have done reasonably well, better than red sex links. But the individual genetics, and the line they come from, can make a difference. When purchasing chicks from anywhere, there is no way to know. The particular strain of Marek's and it's virulence can make a difference also.
Good luck moving forward. I look at it as just another challenge, which I'm managing alright at this point.