I have an Uncle that had to have his leg removed. Before it was removed he did construction work. After it was removed he started his own construction company and was climbing all over the houses they built. The only problem he had was someone had to go get his crutches for him if he ended up going down at a different place than he went up. It's all a mindset thing and if your brother is having other problems due to the leg then hopefully his mind will be set that life will be better afterwards.
Best wishes and prayers for your brother and your family.
Let us know how things go.
Best wishes and prayers for your brother and your family.
