Hello and welcome! I live across the river from you a few miles, so we pretty much have the same varmint problem. In a nutshell, the 4 legged kind include Raccoons, Opossums, coyotes, dogs, and assorted others. For all of those you need 1/2" hardware cloth on windows, vents and at least around the bottom of the runs. The other option around the run is to run an electric fence. Lots of good threads on here to peruse for ideas on that. One I liked in particular was the Omak Coop by Dave Omac, go to post 49 on page 5 for his how to. Sorry, I can't cut and paste at the moment, will come back later and add. Here it is.
https://www.backyardchickens.com/t/915975/electrifying-my-coop-with-an-electric-fencer-how-i-did-it
For Hawks and eagles you can give them lots of shelters nearby to get under quickly, or use wire overhead, again, lots of different methods here to research and see what works for you. Owls are another potential problem, but if you have a secure coop they go into before dark they should be safe. Good luck and have fun.