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Acute Toxicity and Tolerance of Fenbendazole
Acute Toxicity and Tolerance of Albendazole
- LD50 acute, rats, p.o > 10000 mg/kg
- LD50 acute, cattle, p.o 750 mg/kg
- Livestock, pets and poultry usually tolerate fenbendazole very well.
- Safety margin (usual therapeutic dose in cattle & sheep: 5 to 10 mg/kg; in dogs and cats 20 to 50 mg/kg):
- Cattle ≥20
- Sheep: ≥500
- Horses: ≥100
- Dogs: ≥10
- Cats: ≥3
- Pigeons: 3
Acute Toxicity and Tolerance of Albendazole
- LD50 acute, rats, p.o 1.55 to 3.25 g/kg
- LD50 acute, cattle, p.o. 300 mg/kg
- LD50 acute, sheep, p.o. 200 mg/kg
- Safety margins:
- Cattle 7,5 - 10; tolerate up to 45 mg/kg without symptoms (usual therapeutic dose is 5 to 10 mg/kg)
- Sheep: 5 - 10; tolerate 40 to 100 mg/kg without symptoms (usual therapeutic dose is 5 to 10 mg/kg)
- Dogs: NEL (no effect level) in 1-year chronic toxicity studies was 0.35 mg/kg/day p.o.
- Dogs: treatment against Giardia (25 mg/kg 2x/day, 5 days, followed by 50 mg/kg 2x/day, 5 days) caused reversible pancytopenia (reduced number of white and red blood cells) due to damage to the bone marrow.
- Cats: treatment against Paragonimus (25 mg/kg 2x/day, 4 days) caused reversible pancytopenia, and in some cases lethargy and depression.
- Alpacas: oral treatment ar 19 mg/kg during 5 days caused toxic symptoms (aqueous diarrhea, dehydration and leukopenia) resulting in death in spite of intensive therapy.