That is what I do. My coop is inside of a barn, so it is basically a big 5X8 cage that sits on concrete blocks to keep it up off of the dirt floor. The "floor" of the coop is just 2X4 beams with hardware cloth. I bought several horse stall mats and cut them into 3 large strips and laid them over the floor. I deep clean the coop twice a year and it is a snap. I take out all of the straw, then I lug out the mats, take them outside and hose them down. It is so easy and not very messy. Since my coop is a cage is is so easy to clean, a wire scrubbing brush and a hose is pretty much all I need. I love those mats, they were a great investment.
Oh, when I cut the mats and laid them in the coop there were some small gaps where the mats met. I just put duct tape over the crack where the mats met, and that prevents any straw or dirt from falling through the crack onto the dirt floor below.