I'll go out on a limb and say that the normal dose to treat tapeworms is not more than 10mg/kg once by mouth, but I am *not* a vet, lol.
From: http://parasitipedia.net/index.php?option=com_content&view=article&id=2695&Itemid=3023
Acute Toxicity and Tolerance of Praziquantel
- LD50 acute, mice, p.o. 2000-3000 mg/kg
- LD50 acute, mice, s.c. 7000 mg/kg
- LD50 acute, mice, i.p. >2000 mg/kg
- LD50 acute, mice, i.m. >2000 mg/kg
- LD50 acute, rats, p.o. 2000-3000 mg/kg
- LD50 acute, rats, s.c. 16000 mg/kg
- LD50 acute, rats, i.p. 600-800 mg/kg
- LD50 acute, rats, i.m. >1000 mg/kg
- LD50 acute, dogs p.o. >200 mg/kg. It is not possible to determine a lethal dose >200 mg/kg after oral administration because such doses cause vomit.
- LD50 acute, dogs: s.c. >3000 mg/kg
- Praziquantel has a hIgh safety margin (~40). Usually dogs, cats and livestock tolerate praziquantel very well.
- Puppies 4 to 5 weels old tolerated oral or parenteral doses of up to 55 mg/kg very well.
- In dogs, daily administration of 60 to 180 mg/kg during 4 weeks cause no sings of toxicity. Parenteral doses of 200 mg/kg caused transient vomit, salivation (drooling) and/or depression.
- In cats, parenteral administration of 50 to 100 mg/kg caused ataxia (uncoordinated movements) and depression. Parenteral doses of 200 mg/kg were fatal.
- In birds praziquantel overdose is toxic for the liver. Injectable praziquantel is fatal for finches.
-Kathy