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I'll go out on a limb and say that the normal dose to treat tapeworms is not more than 10mg/kg once by mouth, but I am *not* a vet, lol.




From: http://parasitipedia.net/index.php?option=com_content&view=article&id=2695&Itemid=3023
Acute Toxicity and Tolerance of Praziquantel

  • LD50 acute, mice, p.o. 2000-3000 mg/kg
  • LD50 acute, mice, s.c. 7000 mg/kg
  • LD50 acute, mice, i.p. >2000 mg/kg
  • LD50 acute, mice, i.m. >2000 mg/kg
  • LD50 acute, rats, p.o. 2000-3000 mg/kg
  • LD50 acute, rats, s.c. 16000 mg/kg
  • LD50 acute, rats, i.p. 600-800 mg/kg
  • LD50 acute, rats, i.m. >1000 mg/kg
  • LD50 acute, dogs p.o. >200 mg/kg. It is not possible to determine a lethal dose >200 mg/kg after oral administration because such doses cause vomit.
  • LD50 acute, dogs: s.c. >3000 mg/kg
  • Praziquantel has a hIgh safety margin (~40). Usually dogs, cats and livestock tolerate praziquantel very well.
  • Puppies 4 to 5 weels old tolerated oral or parenteral doses of up to 55 mg/kg very well.
  • In dogs, daily administration of 60 to 180 mg/kg during 4 weeks cause no sings of toxicity. Parenteral doses of 200 mg/kg caused transient vomit, salivation (drooling) and/or depression.
  • In cats, parenteral administration of 50 to 100 mg/kg caused ataxia (uncoordinated movements) and depression. Parenteral doses of 200 mg/kg were fatal.
  • In birds praziquantel overdose is toxic for the liver. Injectable praziquantel is fatal for finches.


-Kathy
 
Compare the above to the same for Safeguard:

http://parasitipedia.net/index.php?option=com_content&view=article&id=2699&Itemid=2987
Acute Toxicity and Tolerance of Fenbendazole

  • LD50 acute, rats, p.o > 10000 mg/kg
  • LD50 acute, cattle, p.o 750 mg/kg
  • Livestock, pets and poultry usually tolerate fenbendazole very well.
  • Safety margin (usual therapeutic dose in cattle & sheep: 5 to 10 mg/kg; in dogs and cats 20 to 50 mg/kg):
    • Cattle ≥20
    • Sheep: ≥500
    • Horses: ≥100
    • Dogs: ≥10
    • Cats: ≥3
    • Pigeons: 3
 
I'll use my 8 week old BS as an example. Pretty sure if I put him on a scale today he'll weigh about 1kg. Based on what I have read and what my vet has told me, the maximum dose of metronidazole for him would be 50mg once or twice a day, so that's 1/5th of the API General Cure package once or twice a day. That 1/5th also has 15mg praziquantil, which is probably fine at that amount.

What I need to do is figure out a way to make a solution using powder or pills... I already tried with water, but the two pills I tried it with don't actually dissolve and they settle before I can syringe up the correct dose. Need to find something that keeps the particle suspended.

-Kathy
 
Hey @casportpony ! I don't have any peafowl... yet... but I have been watching this thread. If you have solid tablets you need to levigate into a liquid your best bet (if they are not entericoated) is to crush them in a mortar and pestle until they are a very fine powder then SLOWLY add liquid. Start with a few ml's at a time until you have a paste (if the birds wont be bothered by it a simple syrup would work best) then add liquid after that point until desired consistency!


I am a pharmacy technician by day so I have to do that... a lot.. ugh
 
Quote: No, the dose is no less than 30mg/kg by mouth once a day for five days, but some vets will prescribe up to 50mg/kg by mouth twice a day for 5-14 days.

Pills are the best way to go and it really does need to be given orally, not in the water.
big_smile.png


-Kathy
 
Hey @casportpony ! I don't have any peafowl... yet... but I have been watching this thread. If you have solid tablets you need to levigate into a liquid your best bet (if they are not entericoated) is to crush them in a mortar and pestle until they are a very fine powder then SLOWLY add liquid. Start with a few ml's at a time until you have a paste (if the birds wont be bothered by it a simple syrup would work best) then add liquid after that point until desired consistency!


I am a pharmacy technician by day so I have to do that... a lot.. ugh
Exactly... I tried with one 250mg tablet and 5ml of water, but that didn't give me the desired effect, so my next step was going to be to try with corn syrup. Thanks for the tip, I will try that. My goal is a 50mg/ml solution.

-Kathy
 
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If anyone needs help calculating a dose, just let me know and I'll do it for you. If you don't know how much it weighs, just tell me the age and sex of the bird. It won't be as accurate as weighing, but it will be close enough unless the bird is really small or big for it's age.

-Kathy
 

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