At this new farm, we've yet to see a coon... We have caught a baby possum in our live trap once last year but no other signs of possum. I'm assuming because of the foxes.... I've got at least one vixen with 2 kits last year and this year. I've also seen a red fox and heard coyotes so I think they pretty much keep the larger pests away. So far the foxes & coyotes can't get into the runs at all, plus our dog helps deter them because our backyard is adjacent to both coops. That just leaves the mice & rats. I've seen rats in the barn on occasion but none in the coops. Mice are the biggest issue out there and I agree, they cause disease. Plus they stink and are just overall disgusting.... The live trap instructions say to release them at least 2 miles away. The place I take them is well over 6 miles away. With the amount of hawks, owls, other birds of prey, foxes, coyotes, cats, dogs, bobcats, etc....I really don't worry that they will find their way back. We live in the Ozark foothills so its not flat terrain. Also, the state park is hundreds of acres. It is unlikely that a few dozen mice I release there are going to affect the ecosystem much.