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It will depend on the line and how well it's been taken care of before you got it. With proper selection, lines can be inbred for many generations. In fact, inbreeding is very useful to fix traits and to remove unwanted recessives from the line. If you have reasons to suspect problems, then it may help. Keep in mind, an out-cross to vastly different linage can take years to clean up. Pick your poison carefully.
It will depend on the line and how well it's been taken care of before you got it. With proper selection, lines can be inbred for many generations. In fact, inbreeding is very useful to fix traits and to remove unwanted recessives from the line. If you have reasons to suspect problems, then it may help. Keep in mind, an out-cross to vastly different linage can take years to clean up. Pick your poison carefully.