My mom died the day after her 60th birthday, of Granulomatosis with polyangiitis, fka Wegners disease. Back then (1985), nobody really knew much about it, so there really wasn't a diagnosis or treatment, in her case.
The summer before she passed, she asked me, "What should I do with the house when I die?" (She owned it before she married the second time, so it was legally hers.) I thought that was a really strange question, since my step dad was 11 years old than she was. She felt she would pass first?
I think she knew. And my psycho cousin had just made it just too tiring for her to keep going.