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Some folks never worm, others worm only if they find worms in the stools. I choose to worm once a year. A loss of weight, the color of their combs being "off", just a run down look is what you'd see. Most animals, chickens included, can handle a small worm load fine.
I use valbazen (albendazole) which is a cattle/sheep wormer, used "off label". Valbazen is also commonly used to treat worms in humans. Ivermectin is another cattle wormer, used off label.
Valbazen has a two week egg withdrawel time, meaning you toss eggs for two weeks.
IMO, DE is more of a preventive than an actual wormer. It won't take care of a large worm infestation. Another natural wormer some folks swear by is buttermilk and pumpkin seeds. If you do a search, keywords "pumpkin seeds" you'll probably find multiple threads on their use.