A 400 pound guinea would think you were one tasty morsel I'm betting! Can you imagine those nails on a 400 pound guinea?

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I'll vote no...a average sized person is maybe 1/3 to 1/2 of 400 pounds? I don't see my guineas killing any mammals that are 1/3 to 1/2 their size now.
I think if you were 1/10 of their size, all bets might be off, though....
Now, if they had opposable thumbs, they could probably take over the world until they forgot what they were doing and ran off to do something else.