Necropsy- visceral gout

Need some help from experienced folks. Had a hen die Sunday night and took her for necropsy. They just called and said that their initial findings is that she had visceral gout.

I had no idea what that meant so did a quick google. Looks like that's typically caused by too much calcium and dehydration.

So the hen was weak and excessively thirsty when I found her. Her crop was full of water and smooshy.

Any ideas what happened? Why would she be drinking so much yet dehydrated?

So I'm concerned that the feed I've been giving them isn't pullet developer but turkey grower. The company makes both and when I opened it I noticed the nutritional tag was missing but didn't think much of it. It looked like crumbles so figured it be either starter or pullet developer. Didn't think about it being turkey grower. Arg. I hope that's not what caused this as my other hens will be suffering as well.

Sorry for your loss... It can be caused by a diet too high in calcium, one too *low* in phosphorus, one too high in protein and chronic dehydration. The turkey grower has probably 25-30% protein, but not much calcium. Probably a good idea to switch to a lower protein diet and wait for the final report as it's possible there was an underlying disease that caused dehydration.

-Kathy

More to read from:
http://en.engormix.com/MA-poultry-i.../avian-gout-causes-treatment-t1246/165-p0.htm
Avian Gout

Avian Gout: Causes Treatment And Prevention

Published on: 05/26/2009
Author/s : Dr. M.T.Banday, Dr. Mukesh Bhakt and Dr. Sheikh Adil Hamid - Srinagar, Kashmir, India

Today’s bird is genetically engineered for higher productivity. Selection of birds is based on production parameters. In the process, the health of the vital organs is ignored. This has resulted in increased incidence of metabolic disorders. The kidney is a vital organ of the bird with diverse metabolic and excretory function viz. maintaining the chemical composition of body fluids, removal of metabolic waste and toxic products, regulation of blood pressure and blood volume and conservation of fluids and electrolytes.

Excretion of metabolic waste products is important in poultry and this function is performed by the kidneys. The function of kidneys is affected by a number of specific diseases and disorders. One of the important disorders associated with kidney damage is GOUT. In birds uric acid is the end product of nitrogen metabolism. Uric acid is a nitrogenous waste from protein breakdown. In mammals, it is converted to less harmful substance with the help of the enzyme uricase. But in birds this enzyme is absent. Hence, uric acid is the final excretory product. Uric acid is produced mainly in the liver and is excreted by the kidneys. High blood levels of uric acid favour its precipitation in tissues. Uric acid is not toxic but precipitated crystals can cause mechanical damage to tissues like kidneys, heart, lungs, intestines and also in the joints. These crystals severely damage body tissues. So Gout is a condition in which kidney function decreases to a point where uric acid accumulates in the blood and body fluids. Avian gout is a metabolic condition where abnormal accumulation of white chalky uric acid or urates occurs in soft tissues of various organs of body. Gout is commonly observed in chicken as they are uricotelic and lack the enzyme uricase. In gout, blood levels of uric acid can be as high as 44mg/100ml as compared to 5-7mg/100ml in a normal bird.

There are two major forms of gout which are differentiated by the sites of uric acid deposition- visceral and articular gout. In both forms, deposits consist of needle shaped crystals called tophi. Articular gout is considered to be the chronic form of the disease and is less common. Lesions observed are urate deposition around joints, ligaments and tendon sheaths. There is a predilection for peripheral articulation. Clinical signs observed are shifting leg lameness with joints becoming warm, swollen and tender. It is a condition in chicken that has been recognized for more than 30 years. Visceral gout is considered to be the acute form of disease causing huge mortality characterized by the urate deposits on serosal surfaces, most often in the liver, kidney, pericardium, heart and air sacs. Visceral gout is more common in broilers as young as 2-3 days old. In layers, pullets above 14 weeks are more likely to be affected. whenever there is kidney damage, excretion of uric acid gets affected and uric acid starts accumulating in the blood and later in tissues.


CAUSES OF GOUT

The causes of gout are many as kidney damage occurs due to multietiological factors. These causes can be broadly categorized as:

• Nutritional and metabolic causes
• Infectious causes
• Other causes

NUTRITIONAL AND METABOLIC CAUSES:

1. Excess dietary calcium with low available phosphorus results in precipitation of calcium-sodium-urate crystals. High levels of vitamin D3 can also increase calcium absorption from the gut which can favour formation and deposition of urate crystals.
2. Excessive use of sodium bicarbonate when used to combat heat stress to improve egg shell quality in layers. This alkalinity of urine favours kidney stone formation.
3. Prolonged vitamin A deficiency causes sloughing of tubular epithelium and subsequent blockade resulting in accumulation of urates in the kidney. However, incidence of gout due to vitamin A deficiency is least under field conditions.
4. Gout due to sodium intoxication is seen in younger birds when the sodium levels exceed 0.4% in water and 0.8% in feed. This generally happens when fish meal is used in the diet (even with normal salt content), since fish meal is rich in salt content. Total content of sodium chloride in feed should not exceed 0.3%.
5. Feed containing more than 30% of protein causes uric acid production which in turn creates an excretory load on kidneys. At the same time the presence of sulphates decreases calcium resorption causing excessive calcium secretion through urine. This condition favours gout.
6. Water deprivation leads to concentration of uric acid and other minerals in the blood and later in the kidneys. Water deprivation especially in the summer is dangerous. This can happen during transportation of birds or due to blockage of nipples, inadequate number of waterers, extra height of water lines, overcrowding, water withholding for long durations during vaccination etc.
7. Hard water with higher salt content is also a load on the kidneys.

OTHER CAUSES:

Various chemicals and toxins are involved in kidney damage as;

1. MYCOTOXINS: Mycotoxins are the most common cause of kidney damage and among mycotoxins citrinin, ochratoxin and oosporin are important. The combination of ochratoxins with aflatoxin is found to be more dangerous. Because of kidney damage uric acid excretion is reduced resulting in accumulation of uric acid in the body.
2. ANTIBIOTICS: Certain antibiotics like gentamycin, sulphonamides and nitrofurosones are known to cause renal damage especially in young chicks. The drugs which get excreted through the kidneys have their own imbalancing effect on pH and renal metabolism.
3. DISINFECTANTS: Disinfectants like phenol and cresol if used erroneously cause residual toxicity.
4. CHEMICALS: Chemicals like copper sulphate used in water results in water refusal, dehydration and gout.

SIGNS AND LESIONS

Gout is characterized by depression, dehydration and sometimes with greenish diarrhea. Affected chicks appear dull with ruffled feathers and moist vent. Mortality among young chicks is high. There is irregular and excessive enlargement of kidney lobules and cutting open the kidney reveals urate crystals chalky white deposition of urate crystals is seen all over the visceral organs like the heart, liver and kidney under the skin etc.




SEVERE VISCERAL GOUT - Note the white chalky deposits around the heart (in the pericardium), on all major abdominal organs, including liver, gizzard and intestines, and even in the tissues of the thigh.



TREATMENT

Individual cases of gout may be ignored. In acute cases of gout mortality following prescription would be beneficial.

1. Provide plenty of water and adequate drinkers.
2. Avoid a diet higher in protein than the recommended level as per the age and breed. Provide low protein diet for 3-5 days based on need depending on severity of gout.
3. Review IB vaccination programme. In the areas where IB is endemic it is advisable to vaccinate with nephrotropic strain at around 4 days. Day one beak dip vaccination has proved to be beneficial in broilers.
4. Use of urine acidifiers: Any one of the following urine acidifiers may be given in water or feed.
   • Vinegar: 1-2 ml per litre water up to 24 hours.
   • Potassium chloride: 1gram per litre water up to 24 hours.
   • Ammonium chloride: Two and half kg/ton feed for 7 days.
   • Ammonium sulphate: Two and half kg/ton feed for 7 days.
5. Ensure adequate levels of A, D3, K and B complex vitamins.
6. Excessive use of sodium bicarbonate i.e. more than 2kg/ton should be avoided.
7. Use of electrolytes through water may assist in controlling mortality.
8. Provide broken maize at least for 3 days and jiggery 5g/litre for 3-5 days in case of mortality.
9. Provide 0.6% methionine hydroxyl analogue free acid with 3% calcium in the diet.

PREVENTION

For the prevention of gout in poultry it is necessary to have:

1. Scientifically balanced feed in respect of:
   • Calcium-phosphorus ration depending on the type of ration.
   • Vitamin A, D3 and other essential vitamins.
   • Required level of sodium, chloride and other ions.
   • Conventional sources of protein.
2. Analyse the feed for mycotoxin content and if found positive change the feed or use suitable toxin binders.
3. Judicious use of drugs such as antibiotics, sulpha drugs and anticoccidials to avoid kidney damage.
4. Fresh potable water accessible to birds all the time.
5. Copper sulphate should not be used for medication, if used should be used under the directions of a veterinarian or a poultry practitioner.

Thanks for all the great info! I wish I knew what caused this and if my other hens are in danger.

I'm trying to treat it as a "one hen" thing and just keep an eye on the girls, but am concerned.

Articular gout is usually excessive protein. Visceral gout is usually excessive calcium.
My guess is that a lot of chickens die from visceral gout and the owner doesn't know why. Many people switch birds to layer feed too early and continue layer feed when the birds aren't laying like when they're broody or molting. During these times they should switch to a grower type feed.

Layer feed, which is approximately 4% calcium is too high for a bird not making egg shells. This includes roosters.

She was drinking to try and flush the kidneys.

A lot of people including myself, who have roosters, chicks, and broody or molting hens will feed an all flock or flock raiser type feed while always keeping calcium in the form of crushed oyster shell and crushed egg shells available in a separate container. Chick feed is almost identical to flock raiser. Some flock raiser feeds come in pellet form too. Southern States sells Rockin Rooster Growth Booster which is pellets.

ChickenCanoe said:

Articular gout is usually excessive protein. Visceral gout is usually excessive calcium.
My guess is that a lot of chickens die from visceral gout and the owner doesn't know why. Many people switch birds to layer feed too early and continue layer feed when the birds aren't laying like when they're broody or molting. During these times they should switch to a grower type feed.

Layer feed, which is approximately 4% calcium is too high for a bird not making egg shells. This includes roosters.

She was drinking to try and flush the kidneys.

Click to expand...

I have seen that you did say "usually", but thought i should share this:

The feedstore I go to was feeding their peachicks turkey starter, which has very little calcium, right? Three of their chicks died, so I sent them off for necropsy at UC Davis. Necropsy found coccidiosis in three and one of those also had visceral gout, probably due to dehydration, but certainly not excess calcium.

-Kathy

Tracyree said:

Thanks for all the great info! I wish I knew what caused this and if my other hens are in danger.

I'm trying to treat it as a "one hen" thing and just keep an eye on the girls, but am concerned.

Click to expand...

You might want to add more water sources.

-Kathy

Absolutely. There are always exceptions.

Visceral gout is simply the inability to excrete urates. The causes could be anything from water deprivation (which I suspect with the chick) fungus, genetics, disease, vitamin deficiency, excess sodium, protein, etc..

I just said that I usually suspect excess calcium because so many people don't pay attention to the fact that not all of their birds are producing eggs and can't handle the 4% dietary calcium.