I have never had prednisone prescibed until a few weeks ago. I had the strangest sensation that poisin was dripping from my brain into my body. I felt miserable and cried every 5 minutes. I felt I had to give it an opportunity to do what it was supposed to which was address chronic pain in my knee. Anyway, it had no affect on my knee and made me feel lousy. I have heard horror stories of people committing suicide on it. I really have to wonder why they would prescribe such a nasty drug and I am a person who has no qualms about taking medications. A very nasty drug.