I work in research as well and you have pretty much nailed the main concerns on the head.
Animals of any stripe get too inbred and strange things start happening. Transgenics are super special.Start breeding for knock outs and double knockout and wow does it get weird. Our biggest problem is epilepsy. There is also a long list of behavioral problems that crop up. I would worry about this with chickens as well. Still out crosses should be done very carefully I would imagine to preserve type. There is definitely a place for both schools of thought.![]()
I worked in the radiation lab at UCSF with lab animals for 4 years, (rats, mice, toads and back then beagles), so I have an understanding of lab animals. I still subscribe to Lab Animal magazine. They are not like chickens. Genetic diversity in chickens does not have to be achieved by bringing in new blood if they are under the control of a knowledgeable breeder and chicken breeding is like no other breeding I have seen. Chickens can have structural changes just by making color changes.....and this is in a closed flock with no other genetic influence. I can't explain it, but I have seen it over the many years I have been doing this. chickens are complex genetically. Chickens also have behavior problems, but it is mostly aggression and those you plant in the garden as they are genetic.
The knowledgeable folks that post in this thread don't necessarily put happy faces and lol's in their posts, it is just their opinion based on many years of actually doing this stuff.
This thread and the OT thread are the only ones I know of on BYC that are not coffee clatches, so you may read some things that aren't happy and agreeable here occasionally.
All schools of thought are welcome here, but we don't have to agree with them.
Walt