Natural alternatives that are toxic enough to kill insects are still toxic.
I give up on the "all natural" ideologies a time ago. There is nothing natural about planting non native species in a strange and hostile environment. I try to garden responsibly. If there is an organic option that is a more responsible option, then it is preferred over the others. Because a compound is organic in nature, does not necessarily mean it is less toxic than it's synthetic counterpart. I would agree when it is.
It is always going to require extra care and maintenance forcing non natives. Our taste buds want one thing, but we want to live somewhere else.
We eat what we are accustomed to. If we are able to adjust our expectations as we can and do with meat, we can do better. What that means is different things for different people. It does not have to be a native. It should however, be well adapted on it's own.
I still grow things that I need to spray, but more and more, I have been getting away from it. Especially in long term plantings like trees and shrubs.
I am not suggesting anything, but sharing a perspective.
For fruit I have almost completely gone with natives. Rabbiteye Blueberries, Muscadines, Blackberries, Hybrid Persimmons, Paw Paws, Mulberries, Passion Fruit etc. I do not have to spray any of these. I do have Figs, but they do not require any spray here. Plenty of fruit and no spraying.
I like to emphasize fruit.
I live in the humid southeast, and we are challenged by many pests, funguses, blights, viruses, etc. Most non native fruits require a regular spray schedule here.
My best and native nut tree is the Pecan. No spraying. I also enjoy some native Black Walnuts. They are ore of a treat than anything else, for me.
I try to time the vegetables as smartly as I can. I plant some things early, and some things late trying to avoid peak seasons for certain pests or weather extremes that stress them and make them more vulnerable.
As much as I hate to, I go with bush beans. I can get my crop(s) faster. The longer they are in the ground, the more likely I need to spray. I may settle with an early crop of Potatoes rather than spraying. I plant a little more than what I need.
I have a patch of Jerusalem Artichokes that I appreciate more and more. They are essentially free food once established.
When I do feel like I need to spray, I go with what is cost effective and effective. I go with what I can get reliable information on. Then I follow the directions.