I am not familiar with any of the antibiotics you mentioned; without thorough research, you are risking possible drug side effects using them on her. Instead of using what you have on hand, you may consider ordering online. There are several antibiotics such as cephalexin, or enrofloxacin that would likely prove effective in treating the pododermatitis you're seeing.

https://allbirdproducts.com/products/baytril-10
https://www.chewy.com/fish-aid-antibiotics-cephalexin/dp/185208

If you decide to start antimicrobial therapy, surgical removal of the caseous material likely present in the swelling is essential for proper healing. Oftentimes, soaking the foot in either an Epsom salt or antiseptic mixture, while massaging the sores, offers easier removal of the material by loosening the scab, and "tenderizing" the tissue. After soaking, a surgical incision should be done on significant areas of swelling; after an incision is made, firm pressure should be applied to the area to squeeze out any caseous material, or puss.

Frequently, you will experience hemorrhaging of the tissue; if that occurs, apply firm pressure with a dry towel until hemostasis is achieved, and continue further on. If the procedure works well, and debridement of the area as been accomplished, a good lavage of the sore using an antiseptic would be suggested. Follow that with an application of an antibacterial ointment, then a gauze/vet wrap bandage. in the beginning, the bandage should be changed every day, and if needed reapply the ointment.

Pododermatitis is characterized by inflammation, degeneration, and infection of the footpads. There are many etiologic, and predisposing factors, but a predominant cause among ducks seems to be degradation, and erosion of the squamous epidermis, resulting in flaking, and bacterial invasion into the tissue. The sequence can be promoted by housing birds in an unforgiving environment that promotes degration. Unfortunately, oftentimes even if environmental changes are met, bumblefoot may still occur. This statement is especially true in Pekins where more overall weight pressure is applied to their feet.

Promoting soft, dry, clean housing substrate, and ensuring birds are on a well-formulated diet can help reduce the reoccurrence of bumblefoot.
 
cefuroxime is a second gen cephalosporin, same class as cephalexin. I’ll order the other meds you’ve mentioned. Do you know the dosages by chance? It’ll probably take 2-3 days to arrive, should I continue the penicillin in the mean time?

also, you mentioned that there were 2 spots that needed surgery. What’s the other one other than the heel?
 
cefuroxime is a second gen cephalosporin, same class as cephalexin. I’ll order the other meds you’ve mentioned. Do you know the dosages by chance? It’ll probably take 2-3 days to arrive, should I continue the penicillin in the mean time?

also, you mentioned that there were 2 spots that needed surgery. What’s the other one other than the heel?

I was under the impression it was a Cephalosporin class antibiotic, but am cautious whether it is compatible with ducks. The Baytril dosage, is 0.05ml per pound, twice daily, given orally for no longer than five days.

If using Cephalexin 250mg, take one pill, crush it finely, dissolve it in with 10ml of water. Mix thoroughly. That solution will contain 25mg of cephalexin per ml of the liquid. Using the dose in Plumb's veterinary guide ( 35-50mg/kg PO QID), you would draw anywhere from 0.64, to 0.91ml, and dose per pound, four times daily.

I would personally stop the Penicillin.
 

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