if you shoot a deer with a .50 bmg in the hind quarter you've got a heck of a track ahead of you.
Chances are slim the deer will go far even with a bad shot to the hind quarter from a 50 BMG, the tissue and bone damage would cripple heavily as well as leaving a huge wound path... A 50 BMG will obliterate the hind quarter, especially if it hits any bones, not to mention the great deal of hydro-static shock, depending on the projectile choice and if it yaws it can easily leave a football sized exit wound in soft tissue...
Now if you take that same deer and shoot in the spine or head with a .22 or you take a neck shot with a 2" broadhead and you drop on site. Now you gonna tell me shot placement don't matter.
For one I never said shot placement doesn't matter, I said it becomes less critical as the caliber size increases and you for all intent just proved that with your response where you compared apples to oranges in shot placement when you dictated specific targets needed to drop a deer with a 22LR, the same accuracy and shot location to drop a deer simply does not hold true for larger calibers...
Lets compare apples to apples...
If you shoot a deer in the spine, head with a 50 BMG like you suggested with a 22LR it will also drop it in place, on the flip side of the apple if you shoot the hind quarter with a 22LR as you laid out in your 50 BMG example chances are it will survive and never drop or at least not drop anytime soon, while the 50 BMG to the hind quarter or basically any 50 BMG body mass hit will almost always cause death in short...
Also I'm confused with what point you are trying to make with the 2" broadhead, that is beyond apples to oranges...