Wanted to unearth this old thread to note a few things. I have some science background so I'm happy to try to explain more if folks have questions or concerns about the chemical side of this. I am
definitely not a medical professional though, so take it with a grain of salt.
Hypochlorous Acid
The active ingredient in Vetericyn is
hypochlorous acid (HOCl). It's a chemical that is naturally produced by white blood cells in our bodies, and it has a wide variety of applications for humans, animals and surface sanitization. HOCl has been used for medical sanitization since the 1800s. It is an excellent antimicrobial but what makes it a standout is that it's extremely gentle. It does not cause skin or eye irritation, so it's my preferred sanitizer for comb and waddle injuries or any rashy skin infections. Hypochlorous acid will also kill many fungi, spores, and viruses (for instance it will kill coronavirus with sufficient contact time) so it's also a go-to for me when I don't know exactly what's going on (yeast? mites? staph? dunno but it looks gross) but want to treat early.
I saw a few posts where people seemed confused about what the actual chemical is, so just wanted to make clear that it's not a type of bleach, nor is it a strong acid like hydrochloric acid. It's a weak acid, which is a totally different pH, but it can be introduced to other chemicals to cause chemical reactions, and all of these chemicals (bleach, hydrochloric acid, HOCl) contain some amount of chlorine. There are many different chlorine-based disinfectants that are used in water sanitation (e.g. pool chlorination and also drinking water treatment), but they have widely different levels of safety. HOCl is very mild but also very unstable, which is why concentration is so important, and I would never try to mix my own HOCl.
Since Vetericyn is pretty expensive, we've sought out other sources of HOCl, and I ended up ordering a gallon from
Pure and Clean which we will be using to refill our Vetericyn bottle. Supposedly this company has an extremely stable product, so fingers crossed this works out for us. The cost is roughly 1/4 the price of Vetericyn.
Chlorhexidine
My main familiarity with Chlorhexidine is in the dental industry where it is used to fight gingivitis. At the time, I was experiencing chronic mouth ulcers, so I was already using an SLS-free toothpaste, which is lucky because sodium lauryl sulfate (a common ingredient in toothpaste and other body cleansing products) inactivates chlorhexidine. From what I can tell, chlorhexidine is a good chemical for
reducing bacterial growth, but not killing bacteria, fungus, or viruses. Unlike HOCl, which is generally inactivated by environmental conditions (e.g. temperature, exposure to light / air, improper dilution), chlorhexidine is inactivated by reacting with other chemicals, some of which we might use for cleaning surfaces (such as SLS). There are even some studies indicating that chlorhexidine may be inactivated by saliva or blood, which could really render it useless as a wound cleanser.
Chlorhexidine has been associated with a lot of good outcomes as an umbilical cord sanitizer and in treating gingivitis, so I would not write it off as a sanitizing agent. It's also much cheaper and easier to store than HOCl, so if you have widespread applications for it (e.g. sanitizing lots of surfaces, or sanitizing umbilicals on large numbers of chicks) it can definitely make sense to use. Ease of storage is really not to be discounted here. If your improperly stored HOCl goes off it's no better than water. I would just be careful about any applications where it might come into contact with soaps / surfactants.
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Some references I found useful:
Hypochlorous acid: harnessing nature’s germ killer - about uses of HOCl in optometry
Chlorhexidine—the good, the bad, and the ugly - about chlorhexidine use in dentistry