Cocci: Corid (amprolium) + Sulfamethoxazole / Trimethoprim

[EggSighted4Life]

Treated ACV in water, wormed the flock, priobiotics and electrolytes.

ACV in the water is probiotics if it's raw and unfiltered.

What wormer? Not all will treat all worms. Weight loss is a normal part of molting and could have even been what induced the runs. What color is it?

 

[casportpony]

Here is something I thought was interesting. Below mentions using sulphaquinoxaline with amprolium. It's a sulphonamide, so probably safe to assume amprolium ca be used with Sulfatrim or any other sulfa drug.

"Amprolium: [1-(4-amino-2-n-propyl-5-pyrimidinylmethyl)-2-picolinium chloride hydrochloride]: it is quarternized derivative of pyrimidine which is a thiamine antagonist. It is most active against E. tenella, E. necatrix and E. acervulina and to lesser extent E. maxima. Combination of amprolium with ethopabate, sulphaquinoxaline or even pyrimethamine extended and strengthened the spectrum of activity. It could be fed at several times the recommended dose with no ill effects and probably, one of the safest antimicrobial drugs to be used extensively. It is effective against 1st generation of trophozoites and schizonts and shows peak activity early in day 3 of cycle. It also suppresses the sexual stages, gametogony and sporulation of oocyst. Continuous use of Amprolium is resulting into the development of drug resistance which is a major problem and limiting its use. It is rarely used alone because E. maxima and other species are resistant and therefore given in combination with other drugs. Amprolium is available as a premix and is given prophylactically to birds in a final concentration of 0.0125 percent. In combination with 2 other drugs, it is given at a level of 0.006% of each in the food with better effectiveness 6. A combination of amprolium and sulphaquinoxaline at levels of 0.006% of each in the food is more effective against poultry coccidiosis than either of the two drugs used alone 7. There is no premarketing withdrawal requirement for this compound. Amprolium is compatible with vitamins, antibiotics, minerals and other ingredients commonly used in poultry ration but it should not be mixed in concentrates containing high levels of choline because of tendency for it to break down into picric acid.

"Sulphonamides: They have the longest history of use as anticoccidial drugs. The common drugs of this group which are used as anticoccidials are sulphadimidine, sulphaquinoxaline, sulphadimethoxine, sulphanitran and sulphaguanidine. Sulphonamides have broad spectrum of activity against eimerian species and have coccidiostatic action. They are used for prevention and treatment of coccidia and in outbreaks. They are more effective against intestinal than caecal forms of coccidia. They stop the onset of the disease by acting against the second generation schizonts of E. tenella and E. necatrix. They can act upon first generation schizonts and possibly against sexual stages but much higher doses are required. Use of these drugs does not impair immunity development."

Source:
http://www.scienceinternational.com/fulltext/?doi=sciintl.2013.261.265

 

[Eggcessive]

Would it be possible to place the affected bird in a dog crate in the coop with her own food and water, and then treat her with the Sulfa while giving everyone else the Corid water for 5 days? Be sure to keep the bedding clean and dry, with occasional removal of droppings, replacing with clean pine shavings, and daily stirring.

 

[casportpony]

Would it be possible to place the affected bird in a dog crate in the coop with her own food and water, and then treat her with the Sulfa while giving everyone else the Corid water for 5 days? Be sure to keep the bedding clean and dry, with occasional removal of droppings, replacing with clean pine shavings, and daily stirring.

That's a great idea!

 

[menotti]

What did you worm the flock with?

Strike III Medicated, like https://www.durvet.com/index.php?option=com_k2&view=item&id=380:strike-3

 

[menotti]

Would it be possible to place the affected bird in a dog crate in the coop with her own food and water, and then treat her with the Sulfa while giving everyone else the Corid water for 5 days? Be sure to keep the bedding clean and dry, with occasional removal of droppings, replacing with clean pine shavings, and daily stirring.

great idea!

 

[EggSighted4Life]

Since this thread is about cocci and there are a few people participating who I'm sure in the past may have seen me say that "MAYBE Nutri Drench was OK to use when treating because it didn't contain any B's..."

I'd like to withdraw that statement and won't be saying it again. Through finally being able to SEE the ingredients, I noticed that though they are not listed in the analysis... thiamine was specifically an ingredient!

This whole getting harder to see thing is really starting to bug.

 

[Wyorp Rock]

Since this thread is about cocci and there are a few people participating who I'm sure in the past may have seen me say that "MAYBE Nutri Drench was OK to use when treating because it didn't contain any B's..."

I'd like to withdraw that statement and won't be saying it again. Through finally being able to SEE the ingredients, I noticed that though they are not listed in the analysis... thiamine was specifically an ingredient!

This whole getting harder to see thing is really starting to bug.

If you look at Plumbs Vet Drug Manual it states under drug interactions when using Amprolium
"""Thiamine: Exogenously administered thiamine in high doses may
reverse or reduce the efficacy of amprolium""" I have not found anything that state what that amount would be - what exactly would be excessive?

I have never found warnings on Corid bottles, labels or their website- if giving vitamins was as dire as sometimes it sounds, then I would think they would have that stated somewhere.

So.....what is the bottom line? For me, it would be best to add vitamins after treatment just in case the amount of Thiamine in a vitamin solution would deem it excessive. But...each situation should be considered - it's not always a one size fits all. Sometimes a vitamin boost may be as necessary to bring a chicken back as given the Corid. Just like sometimes you may see me, for example recommending giving a very ill chick a direct dose of Corid in addition to making the mixed solution available - its sort of like a Hail Mary - it's worth a try, to see if the chick can bounce back.

I'm sure that Kim or Kathy may have other thoughts or even disagree - but each circumstance is different.

Just my thoughts.

fwiw - @EggSighted4Life sometimes if you search for drugs.com you can get a better look at ingredients on some products. https://www.drugs.com/vet/poultry-nutri-drench.html

 

[casportpony]

It's an interesting topic that I don't completely understand. . I read somewhere that when goats are given amprolium they are also given a thiamine supplement during treatment because they are susceptible to thiamine deficiencies.

 

[Wyorp Rock]

It's an interesting topic that I don't completely understand. . I read somewhere that when goats are given amprolium they are also given a thiamine supplement during treatment because they are susceptible to thiamine deficiencies.

Well...LOL to further open a "can of worms" Plumb's Vet Drug manual under dosing says:

!!Birds:
a) For coccidiosis in pet birds: 2 mL (using the 9.6% solution)/
gallon of water for 5 days or longer. Cages should be steam
cleaned to prevent reinfection. Supplement diet with B vitamins.
Some strains resistant in Toucans and Mynahs. (Clubb
1986)
b) For chickens (broilers or layers), turkeys, and pheasants: Refer
to individual product instructions.