I havent experienced this but did some research on this when i had a bad rat problem a year ago. And what I learnt was that the second generation poisons such as brodifacoum can be at 50-100 or more times the lethal dose in the rat by the time it diess, because one feed contains a lethal dose but it takes a week or so to kill so the rat consumes it over and over and it builds up in their system.
Generation one such as coumatetralyl and warfarin dont build up like this as the rat has to eat a number of doses before it consumes enough to kill.
I also noticed that most of the bait sold here, is gen 2 and the advertising was all implying that gen one wouldnt work, that the rats would either be immune or it wouldnt kill enough.
However, thanks to a neighbour emptying all his food scraps into a compost at the fence right beside my place, I had a MASSIVE rat problem as in seeing groups of them runni all over the placeas soon as it was dusk, so many you would almost trip over them if you went outside. Almost like a rat horror movie!
Id tried snap traps, rubber band traps, bucket traps, closing/concreting off all access removal of any food (on my side of the fence anyway), and shooting them, but there were simply too many and their numbers grew faster than I could trap or shoot the,. So I finally accepted I had to use bait. I used a gen one bait and my rat problem was fixed within a couple of weeks and has not returned.
So while i cant comment from personal experience on secondary poisoning, I read that it is definately very possible with gen 2 poisons, and unlikely with gen one. So use gen one if its a concen. Or if you must use gen two. Put it out for one night and remove the next day and suppliment with gen one.
Years ago I worked part time in a vet clinic, and saw a couple of poisoning cases, not sure if primary or secondary poisoning, but its not a nice way to die..I could go into more graphic detail as one cat was opened up when I was present so I saw what it does to their insides....Hence why I had waited till I had no other option before using bait myself..