Some chose to give the shots subcutaneously in the back of the neck under the skin, and they don't have problems. But Tylan is meant to be given into the muscle, and I chose to give it that way--it is better and quickly absorbed. Some also will give it in the leg muscle, but there is always a chance of hitting the sciatic nerve in the leg. Alternate sides of the breast daily.Is it ok if we give her the shot on her back since its already in her system now?