They're all different, but for the most part they're friendly. Some of them are REALLY tame, I can just walk up to them and pet them. Others are a bit hard to catch, and some are almost impossible to catch in open area. But they will all eat out of my hand and none are scared of me (if they know I'm gonna catch them, they run, but if they know I have treats, they come to me; they're pretty smart at figuring it out).
Whisper is fairly easy to catch. If she runs at all, she doesn't run much. She likes being petted and having her head scratched, which is unique. Only one other girl I have likes being petted. However, I've never had a duck that liked being picked up, though some would sit on my lap.
My ducks have never hissed or bit me unless they were broody, which of course was because they were trying to keep me from stealing eggs. But Muscovies don't even lay until 6 months old. If you gently handle her and give her treats, she might eventually get used to being petted, but I don't think she will ever LIKE it.