The vaccine we can buy is only turkey Marek's vaccine. Just the one kind. All you'll want to do is the one time with it. We as non-hatchery folks can't get set up for the other two types as these take specialized equipment to give and keep it viable. It's just how it is I'm afraid....I've gone round and round with the drug company about it and the answer is still no. They won't even sell it to us. The way they do the 2Xs vaccination, at the hatcheries, is to do it once in the egg, at so many days, [not looking at the info right now] and then again after hatch. I have really given this some serious thinking and to be honest the only thing I could come up with is the 1st dosing and then again later at the 4 week mark. I have no clue if it would work or not. I would say yes if you had chicks that were resistant to the first because of maternal resistance initially passed on, but how would you know? If you can afford the two separate bottles of vaccine, then go for it. Why not? It isn't going to hurt them and it may just help. So much of this is into the weird and unknown. I have turkeys here for that purpose. The thought here is that my chickens are constantly being exposed to turkey Marek's and therefore being vaccinated over and over again. I seems to work very well. Somewhere on this thread...I think...I wrote about how my birds were separated from the turkeys over the Winter and how the Marek's showed it's ugly face again. Now, since they are out again, I'm not seeing it. After your eggs hatch and they are ready to go into the brooder, you will want to move them all at once....get your vaccine together and ready to go, do a chick and put into the brooder. Then the next and so on. Unfortunately, this vaccine is one time use, unless you can find the wafer kind and then you may be able to divide it up into two dosings. Have to ask Seminolewind about that one. Practise really, really good biosecurity for the first 6 weeks. Seriously...this is very important, it is during this time frame that the vaccine is working and building up the resitance in the bird's body. Seminole described it as a race as to which virus was going to win. Turkey's or chicken's Marek's, the more careful you can be, the better chance of the turkey Marek's coming out on top. Hogster 160, whatever you do from now on, please think seriously about breeding for your own resistance. It's working here. My Control Group 2 is about ready to lay and I will be hatching from them as soon as is possible. These birds, just like the first group, are healthy, great personalities, and Group 1 is very egg prolific. Kinda like what I thought keeping chickens was supposed to be like, lol. The biggest plus...they don't die. Now read that in a realistic way. They will, but it doesn't seem it will be from Marek's. I know I am still early into this...it will take me a while to get to the 8th group, but every generation is stronger, healthier and huge. I didn't mention that...these birds are large, as in much bigger than I ever thought they would be. Maybe the original survivors were just smaller because of the Marek's and I know some were for fact, but these home hatches are big. Something else I have done here, the Dark Cornish....I had survivors from them, a lot of them as in I only lost one from my original order and that was to cocci. These birds seem to have a natural immunity? I'm not sure if this is the right word or if resistance would be better. They just walked right through it all and are still with me. When and if you decide to breed your own and want to hatch a few of these out, let me know. By then I should have everyone separated out into the breeding pens so you would get the DC and not a mix. Although...the DC and Jersy Giants are a great mix...lol.