I have six dogs that range from a 13 pound Yorkie to a 130 pound Great Dane. I have been using Ivomec 1% Injectable for Cattle for years. (This is mixed with propylene glycol according to the directions belowand given orally to dogs, not injected.) DO NOT USE IVOMEC PLUS!
You can get iPropylene glycol by the gallon at farm supply stores but you do not need that much. Or you can order a 1 quart container of Propylene glycol from most pharmacies for about $15.00 ( DO NOT SUBSTITUTE ETHYLENE GLYCOL, IT IS POISONOUS AND WILL KILL KILL KILL YOUR DOG!
Do not attempt to mix with water as Ivermectin is NOT water soluble. It won't distribute evenly in water, stick with the propylene glycol.
The bottle of Ivomec from a farm supply store will run about $35.00. These bottles will last my six dogs about 3 years of dosing monthly.
This is a page from Garden Web Forum website that gives a great breakdown of what is needed.
RE: Ivomec dosage for dogs... yet again what is this?
Posted by oldpharmacist (My Page) on
Sun, Mar 8, 09 at 12:48
I am a 65 year old pharmacist not a vet. Ivermectin, unlike human drugs, must really have a wide and safe dose range since many of the posts in this thread seem to suggest an overdose of what is really needed to prevent heartworms in dogs. Some of the confusion might be because of the similarity of the words milligram (mg) and microgram (mcg or ug): 1 milligram (mg) = 1000 micrograms (mcg). For me, following the steps below eliminate the confusion. Using the formula in step #5 allows anyone who knows the weight of their dog in pounds to calculate the proper dose in milliliters of the dilution prepared in step #1 for his or her dog.
The commercial product IvomecÂ
1% Injection contains 10 mg ivermectin / 1 ml or 10,000 mcg / 1 ml
1) Take 1 ml (10 mg) of IvomecÂ
1% and dilute it to 10 ml total volume which gives a concentration of 10 mg in 10ml solution. Propylene glycol is readily available so it may be used: 1 ml IvomecÂ
1% Inj. + 9 ml propylene glycol = 10 ml diluted solution with a concentration of 10 milligrams / 10ml which is the same as 10,000 micrograms / 10ml or 1,000 micrograms per 1 milliliter since 1 milligram = 1,000 micrograms. Label this: ivermectin 1,000 mcg / 1ml dilution and write the date on the label of when it was prepared.
2) The dose range of ivermectin for dogs is 0.003-0.006 milligrams/kg body weight (1kg=2.2 lb) or 3-6 micrograms/kg of body weight. All calculations below use the higher dose of 6 micrograms / kg of body weight or 2.72 micrograms / pound of body weight. (This is from the label of the Hartguard box)
3) Therefore a 100# dog (45.45kg) needs a 272 mcg dose: 45.45 kg x 6 mcg/kg = 272 mcg dose
4) The diluted solution prepared in step #1 contains 10,000 mcg / 10 ml or 1,000 mcg / 1 ml or 100 mcg / 0.1 ml therefore the dose in step #3 can easily be calculated: 272 mcg will be contained in 0.272 ml of the dilution prepared in step #1 which can accurately be measured using a 1 ml insulin or TB syringe which is graduated in tenths of a milliliter (0.1, 0.2, 0.3 ml), and which has 10 markings between each increment of 0.1, 0.2, etc. The 0.272 ml dose is measured by drawing up an amount past the 0.2 ml mark plus 7 of the smaller markings almost to the 0.3 ml mark.
5) Using the following formula, a proper dose can be calculated for any dog whose body weight is known:
_______ Weight of dog in pounds X dose of 2.72 micrograms per pound of body weight ÷ 1000 mcg per ml ivermectin dilution prepared in step #1 = dose in milliliters of dilution from step #1
Examples: A dog weighs 77 pounds so 77 x 2.72 ÷ 1000 = 0.21 ml of dilution given in food once a month
A dog weighs 125 pounds so 125 x 2.72 ÷ 1000 = 0.34 ml of the dilution given in food once a month
A dog weighs 12 pounds so 12 x 2.72 ÷ 1000 = 0.03 ml of the dilution given in food once a month
I would use the diluted solution simply because of the 10 fold less chance of error. Measuring 0.21 ml is easily possible while measuring 0.021 ml is prone to error. I would prepare the dilution fresh each season and discard any unused diluted solution at the end of the season. I have read that ivermectin is photolabile meaning it is destroyed by light so both it and the dilution should be stored in a cool, dark place at or below room temperature. It does not seem necessary to refrigerate the solution or the diluted solution.