1. I did not mention Monsanto - but it's a valid example.
2. Small segment of the market or not, glyphosphate-resistant crops are a serious concern to many people, myself included. Your prior statement "glyphosate has nothing to do with most GMO crops" might be technically accurate in that you use the word 'most', but it is at best misleading.
3. Your point that GMO crops are 'less likely' to create runaway effects is simply an hypothesis which some of us do not support testing in the real world.
4. Adaptation through husbandry is not the same thing, in result, as direct genetic manipulation. Glyphosphate resistance is a good example - it is not conceivable that such adaptations would occur without direct genetic intervention.
You may perceive my latter issue as a conflation - I do not. While you may feel that the large multinational agribusiness concerns are altruistic and benevolent, and that direct genetic manipulation poses no environmental, societal, or economic risks others of us do not.
I'm going to address these individually:
1. Monsanto produces glyphosate - they hold the (now expired) patents, and they produce a ton of it - if we're talking about glyphosate, we're talking monsanto.
2. They're a serious concern to you only because you don't understand the science, or are unwilling to read it. This has been studied, with literally TRILLIONS of food trials.
3. Yes, it is a hypothesis - it's called the null-hypothesis - and it's the basis of the scientific method - you don't assume absolutely ridiculous things are going to happen without any evidence - again, a gene is a gene is a gene. It's source doesn't affect how it codes for proteins at all.
4. Organisms naturally becoming resistant to environmental stressors is the basis of evolution via natural selection - and forms the basis of medicine, biology, genetics, and most of science. If you don't believe that organisms can naturally become resistant to pesticides, you're just flat out wrong.
Again, GMO crops, and patenting of food crops are completely separate issues - as is evidenced by there being patented non-GMO food crops. Big-Agriculture is scary, but they can be just as scary without GMO. They're separate issues, and conflating them does nothing but confuse people.