Someone please help

Water Therapy, at least once a day: Let her swim and feed her some peas or mealworms for as long as she enjoys it and stays afloat. Swimming removes the weight from her joints and allows her muscles to strengthen.
After the bath wrap her in a towel and don't let her try to squeeze the water out of her plumage herself. Feathers/down is way more heavier when wet and we don't want to put more stress on her joints than necessary.
If she falls asleep in her towel-nest, let her rest, rest is also very important.
I don't know what breed she is (Pekin/White Layer?) but she looks like one of the heavier breeds to me, So regardless of what you have read here or elsewhere add some Calcium to her diet! Heavier breeds do need that to grow stronger bones that can carry the weight of their heavier bodies. Dark green leafy vegetables and peas are a good source of calcium, so are dairy products.
I would try to feed her some scrambled eggs with some cheese mixed in.
Medication: Niacin plus a multi-vitamin product, she may be suffering from a lack of Selenium too. As a precaution i have mixed ground up OTC B-complex and multivitamin tablets from the pharmacy into the food of all my ducklings.
I would abstain from giving her any anti-biotics, de-worming or cocci medication until the poop-diagnostic expert aka @casportpony has seen and evaluated pictures of what comes out of the other end of the little one. - In other words can you post some of her/his poop 💩?
 
This is why you shouldn't give ducklings any calcium other than what they are getting naturally in their starter.






No adult “layer” food should ever be given to ducklings, not even as an emergency food source. It is toxically high in calcium to ducklings and will cause serious health problems, and even death. ... Ideally, ducklings, should eat a waterfowl starter food.
 
Definitely get the liquid vitamin B in her right away. You can use the stretchy first aid tape that only sticks to itself - fabric like - same thing as vet wrap, to hold her legs in proper position. I would let her swim in the tub for exercise if that is possible, for short periods of time, then carefully warm her afterwards. Eventually start supporting her body and holding her in a standing position for little bits of time to strengthen her legs.
 
Since his chances are dwindling rapidly, maybe try feeding him fish or steak. There are also these threads about how to treat with vitamin b liquids and pills.

https://www.backyardchickens.com/threads/injured-gosling-possible-niacin-deficiency.1467273/unread

https://www.backyardchickens.com/threads/niacin-deficiency-in-waterfowl.1367557/unread

It may be a parasitic pathogen in which you would have to treat specifically, such as cocci. That will be complicated to treat while also giving Vitamin B. I like the people food idea unless you're experienced treating cocci. I've never treated a duck.
How do you feed steak to a duckling? they have no teeth to chew and would need chick grit to grind. Best to stay on the B-complex first and focus on eliminating a niacin def first.
 
You can kind of see the hobbles here.
 

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This is why you shouldn't give ducklings any calcium other than what they are getting naturally in their starter.

No adult “layer” food should ever be given to ducklings, not even as an emergency food source. It is toxically high in calcium to ducklings and will cause serious health problems, and even death. ... Ideally, ducklings, should eat a waterfowl starter food.
Where did you find this statement?
I have fed duckling starter to the ducklings in the brooder, but the ones that have been hatched by my ducks have eaten from the layer pellets that their mommas were eating. They also grabbed their fair share of mealworms, cat-food, lettuce and red-kale from the grown-ups.
There have never been any problems with any of those ducklings…
 

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