@kwhites634 , I have had Lyme outbreaks once with diagnosis and possibly a second earlier time. Doxycycline cured/put me into remission both times. I have since taken part in a Lyme disease vaccination development program. My reaction to the vaccine was worse than when I had the outbreaks. Almost all of my dogs test positive for Lyme's. Only a relatively low number have had outbreaks that responded well to Doxycycline. I really think that almost anyone who spends a lot of time in the outdoors is positive for Lyme. It's just that not everyone shows symptoms.