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Determination of the Anthelmintic Efficacy of Albendazole in the Treatment of Chickens Naturally Infected with Gastrointestinal Helminths
https://doi.org/10.1093/japr/16.3.392
Published:
01 October 2007
Abstract
In the spring of 2006, 60 naturally infected hens obtained from a broiler-breeder farm in northwest Arkansas were used in a controlled titration study to determine the anthelmintic efficacy of albendazole in the treatment of both nematode and cestode infections. Albendazole was used at the dose rates of 0.0, 5.0, 10.0, and 20.0 mg/kg of BW, with all treatments given individually as an oral suspension on d 0 (split doses) and with necropsies for parasite collection conducted on d 7. There were 15 birds per treatment group. Statistically significant (P < 0.05) reductions in worm burdens from control levels were seen at the 5.0 mg/kg dose level for adult and larval stages of Ascaridia galli, Heterakis gallinarum, and Capillaria obsignata. A significant (P < 0.05) reduction in the numbers of Raillietina cesticillus (scolexes) from control group levels was seen only at the 20.0 mg/kg rate of treatment. For albendazole given at the rates of 5.0, 10.0, and 20.0 mg/kg, respective anthelmintic efficacies based on geometric means were 87.7, 91.2, and 98.2% (A. galli larvae); 100.0, 100.0, and 100.0% (A. galli adults); 96.9, 95.7, and 98.9% (H. gallinarum larvae); 92.7, 95.4, and 94.9% (H. gallinarum adults); 90.3, 91.3, and 95.1% (C. obsignata larvae and adults combined); and 73.1, 73.1, and 96.2% (R. cesticillus). No adverse reactions to albendazole were observed in this study.
Source: https://academic.oup.com/japr/article/16/3/392/850127
https://doi.org/10.1093/japr/16.3.392
Published:
01 October 2007
Abstract
In the spring of 2006, 60 naturally infected hens obtained from a broiler-breeder farm in northwest Arkansas were used in a controlled titration study to determine the anthelmintic efficacy of albendazole in the treatment of both nematode and cestode infections. Albendazole was used at the dose rates of 0.0, 5.0, 10.0, and 20.0 mg/kg of BW, with all treatments given individually as an oral suspension on d 0 (split doses) and with necropsies for parasite collection conducted on d 7. There were 15 birds per treatment group. Statistically significant (P < 0.05) reductions in worm burdens from control levels were seen at the 5.0 mg/kg dose level for adult and larval stages of Ascaridia galli, Heterakis gallinarum, and Capillaria obsignata. A significant (P < 0.05) reduction in the numbers of Raillietina cesticillus (scolexes) from control group levels was seen only at the 20.0 mg/kg rate of treatment. For albendazole given at the rates of 5.0, 10.0, and 20.0 mg/kg, respective anthelmintic efficacies based on geometric means were 87.7, 91.2, and 98.2% (A. galli larvae); 100.0, 100.0, and 100.0% (A. galli adults); 96.9, 95.7, and 98.9% (H. gallinarum larvae); 92.7, 95.4, and 94.9% (H. gallinarum adults); 90.3, 91.3, and 95.1% (C. obsignata larvae and adults combined); and 73.1, 73.1, and 96.2% (R. cesticillus). No adverse reactions to albendazole were observed in this study.
Source: https://academic.oup.com/japr/article/16/3/392/850127
