I've taken Zoloft, Cymbalta, Lexapro & Wellbutrin. I was really hoping the Wellbutrin would work for me as most of the other stuff really packed on the pounds but apparently Wellbutrin+bipolar = crazier than usual. I found myself grinding my teeth at night and restraining (barely!) myself from running down other drivers for the slightest infraction. Zoloft didn't do much for me, Cymbalta & Lexapro did though. One thing you want to watch is that a lot of docs tend to prescribe the drugs they're given the most samples of = the companies that throw the most money at them, in effect. I've found this to be especially true of anti-depressants.
Cymbalta was nice because it helps with physical symptoms as well.
Also, be careful - some have NASTY withdrawal. Lexapro gave me what can only be descibed as a feeling of brain tremors. NOT pleasant! I recommend askapatient.com for researching side effects.
Look out world - I'm too poor at the moment to afford any drugs - so I'm totally unfettered. Be afraid.