HELP!! monster hornets nest on run. best way to get rid of it?

[Red Mangrove]

WD-40 after dark. Kills them within seconds

 

[SchwartzLakeFarmNC]

If you live outside of the city limits, a 12g shotgun at night will eliminate the entire nest!

Talstar powder using a puffer at night will kill the entire colony, it's also great for yellow jackets and ant hills, just be careful, those are some nasty buggers.