http://en.wikipedia.org/wiki/Nicotine_poisoning
Toxicology[edit]
The
LD50 of nicotine is 50 mg/kg for
rats and 3 mg/kg for
mice. 0.5-1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children.
[9][14] Nicotine therefore has a high
toxicity in comparison to many other alkaloids such as
cocaine, which in mice has an LD50 of 95.1 mg/kg.
A person can overdose on nicotine through a combination of nicotine patches, nicotine gum, nicotine inhaler cartridges and/or tobacco smoking at the same time.
[15][16] Ingestion of nicotine pharmaceuticals, tobacco products, or nicotine containing plants may also lead to poisoning.
[4][5][6] Smoking excessive amounts of tobacco has also led to poisoning; a case was reported where two brothers smoked 17 and 18 pipes of tobacco in succession and were both fatally poisoned.
[2] Spilling an extremely high concentration of nicotine onto the skin can result in intoxication or even death since nicotine readily passes into the bloodstream following skin contact.
[17][18]
Signs and symptoms[edit]
Nicotine poisoning tends to produce symptoms that follow a biphasic pattern. The initial symptoms are mainly due to stimulatory effects and include nausea and vomiting, excessive salivation, abdominal pain,
pallor, sweating,
hypertension,
tachycardia,
ataxia, tremor, headache, dizziness, muscle
fasciculations, and
seizures.
[4] After the initial stimulatory phase, a later period of depressor effects can occur and may include symptoms of
hypotension and
bradycardia,
central nervous system depression,
coma, muscular weakness and/or paralysis, with difficulty
breathing or
respiratory failure.
[4][1][19][20]