Ivermectin poisoning

[chooks4life]

Good information for those insistent upon using Ivermectin. Why they insist upon it is still baffling. It really serves no purpose for poultry and there are much safer and more effective alternatives.

They continue to use it because it's recommended by some vets and agricultural publications, and they recommend it because it's not totally useless in all areas yet. It still works for some, apparently. But not for an ever growing percentage of others.

 

[casportpony]

Good information for those insistent upon using Ivermectin. Why they insist upon it is still baffling. It really serves no purpose for poultry and there are much safer and more effective alternatives.

I'm having fun making lice swim in it, lol, but have seen enough evidence to convince me that it's completely useless in poultry.

-Kathy

 

[Michael Apple]

They continue to use it because it's recommended by some vets and agricultural publications, and they recommend it because it's not totally useless in all areas yet. It still works for some, apparently. But not for an ever growing percentage of others.

Only in outdated material or those perpetuating outdated material.

 

[Duck Drover]

Well, years ago we used sheep drench for everything!

 

[casportpony]

Ivermectin is still an effective parasite control treatment in four legged animals.

-Kathy

 

[ivan3]

FYI

Insect pharmacology: Channel, Receptors, Toxins and Enzymes
Edited by: Lawrence Gilbert, Sarjeet Gill (2010)

"3. The Insecticidal Macrocyclic Lactones

…The most dramatic differences between application methods are seen with certain insect ectoparasites. While a number of blood-sucking parasites, such as sucking lice of cattle, are controlled by therapeutic doses of macrocyclic lactones administered orally or by injection, chewing lice are generally not susceptible. Topical applications (generally at about a 2.5-fold higher dose rate) are usually highly effective against chewing lice (Strong and Brown, 1987; Vercruysse and Rew, 2002b). Similar results have also been observed in lice on sheep (Coop et al., 2002). While the efficacy and spectrum of these topical formulations against internal parasites is similar to the oral or injectable treatments, this greater efficacy against chewing lice is thought to be a result of a high concentration of the active ingredient on the surface of the skin where these parasites feed (Titchener et al. 1994). Similarly, most of the macrocyclic lactone pour-on formulations for cattle have demonstrated a persistent efficacy against the blood-feeding horn fly and buffalo fly that is not seen with oral or injectable formulations (Vercruysse and Rew, 202b).

This apparent greater efficacy of pour-on formulations against external parasites is presumably the result of deposition of the active compound on, and in, the skin. The high lipophilicity of macrocyclic lactones is likely to result in the formation of depots of active ingredient in skin lipids and oil and fat secretions. This characteristic has been exploited in special formulations of ivermectin that provide long-term residual control of blowfly and lice on sheep (Eagleson et al., 1993a, 1993b; Thompson et al., 1994), and selamectin which controls fleas on dogs and cats for at least 1 month (Bhaoui et al., 2000).

In sheep, topically applied ivermectin is thought to bind to skin lipids and secretions and may be passively distributed around the sheep’s body in this medium following application to a discrete site ((Rugg and Thompson, 1997). Selamectin is thought to selectively partition into sebaceous glands of dogs and cats from where it is slowly released to the skin over an extended period (Hennessy and Alvinerie, 2002).

…Toxicity is generally greater through ingestion by residual contact and compared with other neurotoxic agents, macrocyclic lactones are considered to be relatively slow acting. Intoxicated organisms usually die slowly, often over a period of days, and there is no quick knockdown effect. Death usually follows paralysis and immobility. The comparatively poor contact activity of these compound plus their short environmental persistence generally results in good compatibility with beneficial and nontarget organisms.

…Despite the widespread, intensive use of avermectins against a number of pests with a high propensity to develop resistance, development of resistance has been relatively slow and rare. The rapid reversion of resistance in the absence of selection pressure and the lack of any confirmed cases of cross-resistance make them amenable for use in resistance management programs. However, in order to prolong the longevity of these compounds in the market place, ite will be necessary to minimize selection pressure in practice, especially in high use situations, through proper rotation, good pest management practices, and proper resistance management strategies.”

YMMV (but it wouldn't hurt to look at Draftiemama's thread: https://www.backyardchickens.com/t/457471/a-picture-with-bugs-new-pic-p3 ).

 

[dawg53]

Ivomec products are useless as wormers in POULTRY:
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0450.1989.tb00635.x/abstract
https://www.backyardchickens.com/t/867541/important-information-on-ivermec-warning-autopsy-photos
Post #53 in this link:
https://www.backyardchickens.com/t/...istomoniasis-case-in-chicken/50#post_13135204

 

[jaxchic]

I just wanted to share that I worm my chickens with ivermectin injectable, six drops under the wing directly on the skin of an average sized bird. I have over fifty chickens and have never had an adverse reaction.
Edited to add that have visibly seen the round worms crawling all over the soft poop, to perfect firm stools in just a day or so.

 

[casportpony]

I just wanted to share that I worm my chickens with ivermectin injectable, six drops under the wing directly on the skin of an average sized bird. I have over fifty chickens and have never had an adverse reaction.
Edited to add that have visibly seen the round worms crawling all over the soft poop, to perfect firm stools in just a day or so.

Six drops under each wing or just one wing?

-Kathy

 

[dawg53]

I just wanted to share that I worm my chickens with ivermectin injectable, six drops under the wing directly on the skin of an average sized bird. I have over fifty chickens and have never had an adverse reaction.
Edited to add that have visibly seen the round worms crawling all over the soft poop, to perfect firm stools in just a day or so.

Ivermectin injectable is not a pour on. It cannot be absorbed through the skin, it is injected. Ivermectin pour on is put on the skin and quickly absorbed into the bloodstream. Most likely you're seeing worm infestation as evidenced by you seeing them alive and "crawling."
When you see worms in feces after worming, the wormers paralyze and worms are excreted. There will be little movement, if any at all...they will be dead or dying. See the link above, it is ineffective as a wormer.
If you want to use effective wormers, get you some Safeguard liquid goat wormer or Valbazen liquid cattle/sheep wormer. I've seen the Safeguard liquid goat wormer at Standard Feed and TSC. I bought mine at TSC.