Iceberg, the lettuce people most commonly eat, has no nutritional value, but is harmless to them. Other lettuce like romaine, etc., do contain various nutrients.
They especially like it when the lettuce has bolted from the heat so you pull the whole stalk and throw it in. The bitterness I taste is apparently not offensive to them.
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They'll love it. Ours eat it from the garden when I chuck some in the run. Tonight they left some in there, which was unusual, but as I said in another post, since we switched to crumbles from pellets they eat more of their food and are not as hungry for the treats.