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.22 is a good caliber to learn and get over your fear. small is handy, but it needs to be big enough in your hand so you feel in control of it. my hubby has a .22 deringer that I won't shoot because it's TOO small - can't get a decent grip on it and I don't have the hand strength he does to just pinch it in place.
go to a gun shop and have them get out all the .22 pistols they have, hold each one and see which feels most natural in your hand. if they've got a range where you can try shooting it, or if there's a local range that rents firearms, try shooting it and see how naturally it aims... does it shoot where you think it will? if not, try shooting some others.
nothing is worse than trying to use a gun to defend your animals and finding out that , under pressure, you can't hit what you're aiming at. unless you're going to spend a fair amount of time practicing, you want a gun that fits your hand naturally, and shoots naturally where you think it will.
I'm an NRA cert. instructor and I specialize in teaching women, new shooters, and people with anxiety and fear about firearms... so feel free to ask if I can help.